Acute Lung Injury and Repair: Scientific Fundamentals and by Lynn M. Schnapp, Carol Feghali-Bostwick

By Lynn M. Schnapp, Carol Feghali-Bostwick

Acute respiration misery Syndrome (ARDS) continues to be a tremendous reason behind morbidity and mortality all over the world, and the occurrence is anticipated to extend with the getting older inhabitants a number of scientific problems can start up ARDS, together with pneumonia, sepsis, gastric aspiration and trauma yet regardless of extreme examine during the last forty years, we nonetheless have an incomplete figuring out of the pathophysiology of the ailment and therapy is still mostly supportive. This e-book presents an outline of acute lung harm and service, describes present animal types to check lung harm and stories present methodologies to check and degree lung damage and service. certain emphasis is given to state-of-the-art ideas and techniques and relevance to human sickness. Acute Lung damage and service: medical basics and techniques is an invaluable source for physicians and scientists who're drawn to experimental version platforms for perception into ARDS pathogenesis and therapy innovations. ​

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Extra resources for Acute Lung Injury and Repair: Scientific Fundamentals and Methods

Example text

Still other Cre transgenic mice are available to study lung epithelial cells though they are not lung specific. Transgenic models that utilize promoters active in epithelial precursor cells are active in the endoderm before lung bud formation, and thus may drive expression in extrapulmonary tissues following embryogenesis. 5 before lung and trachea-esophagus separation. 5. While it labels the lung epithelial precursor cells widely, it is not specific to the lung epithelium. Small populations of mesenchyme are also labeled by this strain.

References 1. Manis JP. Knock out, knock in, knock down–genetically manipulated mice and the Nobel Prize. N Engl J Med. 2007;357(24):2426–9. 2. Baron RM, Choi AJ, Owen CA, Choi AM. Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2012;302(6):L485–97. 3. Yoshida M, Korfhagen TR, Whitsett JA. Surfactant protein D regulates NF-kappa B and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J Immunol.

39. Vooijs M, Jonkers J, Berns A. A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep. 2001;2(4):292–7. 40. Hayashi S, McMahon AP. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol. 2002;244(2):305–18. 41. Thyagarajan B, Guimaraes MJ, Groth AC, Calos MP. Mammalian genomes contain active recombinase recognition sites.

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