Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

By Kian Fan Chung

During this booklet, prime researchers in medication and molecular pharmacology clarify the mobile mechanisms that keep watch over airway soft muscle. The skill wherein those are disrupted in illness, and the pharmacologic techniques in which they're changed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the freshest info on one of many middle physiological strategies in airway affliction, and provides insights into present and destiny methods to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most recent study to bronchodilator therapyMulti-contributed textual content, co-coordinated through of the best gurus within the box.

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Am J Physiol 269, L85–L91. , Halayko, A. J. et al. (1992). Ragweed sensitization-induced increase of myosin light chain kinase content in canine airway smooth muscle. Am J Respir Cell Mol Biol 7, 567–573. Johnson, P. , Tamm, M. et al. (2001). Airway smooth muscle cell proliferation is increased in asthma. Am J Respir Crit Care Med 164, 474–477. Kelleher, M. , Abe, M. , Chao, T. S. et al. (1995). Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am J Physiol 268, L894–L901.

There is evidence that alterations both in myosin isoforms and in the expression and activation of proteins that regulate the myosin activation pathway can lead to airway hyperresponsiveness. , 2006). , 2002). , 1995). A sizable body of evidence suggests that alterations in the isoforms and expression levels of contractile proteins and their activating molecules may contribute to increased airway contractility and airway hyperresponsiveness. 3 Cytoskeletal dynamics and airway smooth muscle contraction A new paradigm for smooth muscle contraction The actomyosin cross-bridge interaction and associated regulatory processes provide a mechanism that can account for tension development and active shortening of the smooth muscle cell, but cross-bridge interactions cannot account for the malleability of airway smooth muscle and its ability to adapt to environmental influences.

Mechanical factors determining maximum bronchoconstriction. Eur Respir J 2, 516S–519S. Macklem, P. T. (1990). A hypothesis linking bronchial hyperreactivity and airway inflammation: implications for therapy. Ann Allergy 64, 113–116. Macklem, P. T. (1996). A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 153, 83–89. Maksym, G. , Butler, J. P. et al. (2000). 4 Hz. J Appl Physiol 89, 1619–1632. Matthews, B. , Overby, D. , Alenghat, F.

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