Chemokines in Allergic Disease by Marc E. Rothenberg

By Marc E. Rothenberg

Offers greater than 2200 references to inspire ongoing study! This extraordinary quantity synthesizes the most recent breakthroughs within the fields of hypersensitive reaction and chemokines leading to leading edge paradigms and new innovations in regards to the foundation and remedy of allergic ailments. Considers the organic homes of approximately 60 structurally similar chemokines and over a dozen receptors! shaped to offer an updated evaluate of molecular constitution, gene law, organic houses, and sign transduction pathways, Chemokines in Allergic disorder ·documents the emergence of chemokines as an enormous large relatives of chemoattractant cytokines that advertise the activation and improvement of leukocytes ·illuminates the strategies that keep watch over leukocyte accumulation ·links chemokines with cellphone recruitment and activation in allergic ailment ·explores the advantages of pharmaceutical intervention within the chemokine pathway ·covers the elemental biochemistry, molecular biology, and actual constitution of chemokines and their receptors ·describes transcriptional rules of chemokine expression ·discusses virally caused gene expression as a primary set off of allergic responses in youngsters ·analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages ·elucidates the mobile community excited about the iteration of chemokines in allergic ailments ·highlights pharmaceutical ways for the improvement of chemokine structural analogs, receptor antagonists, and inhibitors of sign transduction ·offers healing suggestions for interfering with chemokines in allergic problems ·and extra! With contributions from forty six across the world revered clinicians, Chemokines in Allergic affliction is an fundamental reference for easy and medical immunologists; allergists; pulmonologists and pulmonary illness experts; physiologists; molecular, mobile, and lung biologists; pediatricians; internists; and graduate and scientific university scholars in those disciplines.

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Chemokines in Allergic Disease

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Nevertheless, the chemokines mainly active on the cells involved in allergic reactionslymphocytes, eosinophils, and basophilsare relatively restricted, making specific pharmacological intervention a promising approach to the treatment of allergic disease. This book is designed to give an up-to-date overview of the molecular structure, gene regulation, biological properties, and signal transduction pathways of the chemokines as well as therapeutic strategies for interfering with chemokines in allergic diseases.

Basic Science of Chemokines and Allergic Disease 5. Animal Allergy Models: Dissecting Chemokine Function D. M. Conroy and Timothy Williams 95 6. Transcriptional Regulation of Chemokines Ya-Fen Chen, An Song, and Alan M. Krensky 115 7. Chemokines and Histamine-Releasing Factors Allen P. [/PU][DP]2000[/DP]End of Citation Page viii 8. Eosinophil Chemokines Marc E. Rothenberg and Nives Zimmermann 151 9. Basophil Chemokines Clemens A. Dahinden 173 10. Dendritic Cells, T Lymphocytes, and Chemokines David R.

Chemokine and Cytokine Cooperativity Ljubov Simson and Paul Stephen Foster 289 15. Chemokine Receptor Signal Transduction Mechanisms Ann Richmond, Wei Yang, and Madhav N. Devalaraja 311 III. Clinical Science of Chemokines in Allergic Disease 16. Chemokines and Disease Andrew D. Luster, Sylvie Abi-Younes, and Andrew M. Tager 339 17. Chemokines in Allergic Asthma Sun Ying and A. B. Kay 383 18. Cellular Sources of Chemokines in Allergic Diseases Omar Ghaffar, Pota Christodoulopoulos, and Qutayba Hamid 403 19.

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